Which symptom is associated with atropine overdose?

Atropine is an anticholinergic medication that works by blocking the action of acetylcholine at muscarinic receptors. This mechanism leads to a variety of physiological responses, including those associated with atropine toxicity or overdose. One notable symptom of atropine overdose is urinary retention.

Atropine inhibits bladder contraction by blocking the muscarinic receptors that mediate the contraction of the detrusor muscle. As a result, this interference can lead to difficulty in urination or an inability to void the bladder, manifesting as urinary retention. This is a significant clinical consideration, as it reflects how anticholinergic activity affects the normal functions of the urinary system.

The other symptoms associated with atropine overdose are more commonly linked to its action on other systems. For instance, excess sweating is often absent due to the anticholinergic effects. Reduced heart rate is contrary to what atropine typically promotes; it usually increases heart rate by blocking vagal effects. Increased appetite does not correlate with atropine use, as its anticholinergic properties can actually lead to decreased gastrointestinal motility and potentially reduced appetite.

Understanding the effects of atropine and its overdose symptoms is crucial for recognition and management in clinical settings, especially in emergency medical situations