Which of the following statements is true regarding Metoclopramide?

Metoclopramide is a medication that acts as an antiemetic and is often used to facilitate gastric emptying. One of its significant considerations in regard to safety is its potential to exacerbate symptoms in patients with Parkinson's disease. This is due to metoclopramide's dopaminergic antagonist properties, which can lead to an increased risk of extrapyramidal symptoms such as tremors or rigidity in patients who already have compromised dopaminergic pathways due to Parkinson's.

Consequently, the accurate advice is to avoid using metoclopramide in individuals with Parkinson's disease to prevent worsening of their condition and avoid additional motor symptoms.

In contrast, the other statements contain aspects that require caution but do not hold the same level of contraindication associated with Parkinson's disease. For example, while metoclopramide can be used with caution in patients with asthma, there is no outright prohibition, and it may even be indicated in specific circumstances. Similarly, while its use in patients with a history of seizures must be approached cautiously, it is not strictly contraindicated. Lastly, metoclopramide is not typically effective for motion sickness, thus distinguishing it from other antiemetics specifically tailored for that use. Therefore, the