Which of the following is a potential adverse effect of Calcium Gluconate?

Calcium gluconate is a medication commonly used to treat conditions such as hypocalcemia and certain types of hyperkalemia and magnesium toxicity. One significant potential adverse effect associated with its administration is tissue necrosis, particularly in cases where extravasation occurs. Extravasation refers to the leakage of the drug into the surrounding tissue during intravenous administration. When calcium gluconate leaks outside the vein, it can cause irritation and damage to the tissue, leading to necrosis, which is the death of cells in a specific area. This is a critical concern in intravenous therapy, and thus it's essential for healthcare providers to monitor the infusion site closely.

While the other options may represent symptoms associated with various medical conditions or different medications, they are not directly linked to calcium gluconate. Therefore, understanding the implications of extravasation and recognizing tissue necrosis as a potential adverse effect helps ensure safe and effective use of this medication in applicable clinical scenarios.