Which of the following is a contraindication for ibuprofen use?

Ibuprofen, a nonsteroidal anti-inflammatory drug (NSAID), is commonly used for pain relief, inflammation reduction, and fever control. However, it has specific contraindications due to its mechanism of action and potential side effects.

Active peptic ulcer disease serves as a significant contraindication for ibuprofen use because NSAIDs can exacerbate existing gastrointestinal issues. They work by inhibiting COX enzymes, which play a crucial role in producing prostaglandins that protect the stomach lining from acid. Reducing these protective prostaglandins can lead to further irritation and potential bleeding in individuals with active ulcers. This risk of increased gastrointestinal bleeding makes it imperative to avoid ibuprofen in patients with this condition.

In contrast, the other listed options do not directly contraindicate ibuprofen use. Chronic cough, recent vaccination, and seasonal allergies do not pose the same level of risk for complications associated with ibuprofen, thus leaving active peptic ulcer disease as the clear contraindication.