Which adverse effect is associated with high doses of ibuprofen?

High doses of ibuprofen can lead to renal impairment due to its effects on the body's ability to regulate blood flow to the kidneys. Ibuprofen, a nonsteroidal anti-inflammatory drug (NSAID), works by inhibiting the production of certain chemicals in the body (prostaglandins) that are involved in inflammation and pain. However, prostaglandins also play a crucial role in maintaining blood flow to the kidneys. When ibuprofen is taken in high doses, it can reduce the levels of prostaglandins, which in turn can lead to constriction of the blood vessels supplying the kidneys. This decreased blood flow can impair kidney function and may lead to conditions such as acute kidney injury, especially in individuals with pre-existing conditions or those who are dehydrated. Thus, renal impairment is a significant adverse effect associated with high doses of ibuprofen.

The other options, while they may have their own associated risks with different medications or conditions, do not specifically correspond to the known pharmacological effects of high-dose ibuprofen.