What significant adverse effect can result from excessive diuresis when taking Frusemide?

Excessive diuresis from Frusemide, a potent loop diuretic, can lead to hypovolaemic shock. Frusemide works by inhibiting sodium and chloride reabsorption in the loop of Henle, which significantly increases urine output. When this diuretic effect becomes excessive, it can result in a substantial loss of fluids and electrolytes, leading to reduced blood volume.

Hypovolaemic shock occurs when the volume of blood is insufficient to maintain adequate perfusion and oxygenation of tissues. The rapid elimination of excess fluids can deplete intravascular volume, leading to decreased venous return and a resultant fall in cardiac output. This condition can cause symptoms such as hypotension, tachycardia, and signs of organ hypoperfusion due to insufficient blood supply.

This highlights the importance of careful monitoring and dosage adjustment when administering diuretics like Frusemide, particularly in patients who may already have compromised fluid status or those on multiple medications. Understanding the adverse effects of excessive diuresis is crucial in preventing potentially life-threatening conditions such as hypovolaemic shock.