What is the primary concern when administering Fentanyl?

The primary concern when administering Fentanyl is respiratory depression. Fentanyl is a potent synthetic opioid that is used for pain management and sedation, but it can significantly depress the respiratory system. This effect can lead to inadequate ventilation and oxygenation, which is particularly dangerous in situations where patients may already be compromised or have underlying respiratory issues.

Opioids like Fentanyl bind to specific receptors in the brain that regulate breathing, reducing the body's urge to breathe, especially when high doses are administered or when combined with other central nervous system depressants. This can result in life-threatening scenarios if not monitored closely and managed appropriately.

The other concerns listed, while they may occur in various contexts, do not pose the same critical risk to a patient's immediate safety as respiratory depression does when administering opioids.