What is an uncommon adverse effect of ibuprofen?

Hypersensitivity reactions are considered an uncommon adverse effect of ibuprofen. While non-steroidal anti-inflammatory drugs (NSAIDs) like ibuprofen are widely used for their analgesic and anti-inflammatory properties, hypersensitivity reactions can occur, though they are not as frequently reported as other side effects. Such reactions might manifest as symptoms like anaphylaxis, urticaria (hives), or angioedema.

On the other hand, skin rash, acid reflux, and frequent urination are more commonly observed effects associated with ibuprofen. Skin rash can occur due to the drug triggering sensitivities in some patients, while acid reflux may result from ibuprofen's ability to irritate the gastrointestinal tract. Frequent urination may not be a direct adverse effect of ibuprofen, but it can occur due to fluid retention or kidney effects in certain individuals. Thus, hypersensitivity reactions stand out as the less common adverse effect among the options provided.