What is a significant adverse effect of Methoxyflurane?

Methoxyflurane is a volatile anesthetic that has been commonly used for pain relief, particularly in pre-hospital and emergency settings. A key consideration when using Methoxyflurane is its potential for renal toxicity, especially at high doses. The metabolism of Methoxyflurane leads to the production of nephrotoxic metabolites which can cause damage to the kidneys. This risk for renal impairment is a significant concern, particularly in patients with pre-existing kidney conditions or those receiving prolonged exposure to the drug.

Monitoring renal function and being aware of dose limitations are important practices when administering Methoxyflurane to mitigate this adverse effect. Other effects, while they may occur, generally do not have the same level of significant concern regarding patient safety when compared to the risk of renal damage associated with Methoxyflurane use.