What complication can occur with Naloxone use in opioid-dependent individuals?

The correct answer is opioid withdrawal syndrome, which can occur when naloxone is administered to individuals who are physically dependent on opioids. Naloxone is an opioid antagonist that works by rapidly displacing opioids from their receptors, reversing the effects of opioid overdose. In opioid-dependent individuals, this reversal can precipitate withdrawal symptoms because the body has become accustomed to the presence of opioids.

Withdrawal syndrome can manifest with a variety of symptoms, including agitation, anxiety, nausea, vomiting, muscle aches, and potentially severe discomfort. This response is particularly significant in clinical settings, as it can lead to distress for the patient and requires careful management. Understanding this aspect of naloxone administration is crucial for healthcare providers to anticipate and manage any adverse effects effectively in patients who have a history of opioid dependence.

The other options do not align with the pharmacological actions of naloxone. Excessive sedation is typically associated with opioid use rather than the use of naloxone, which counteracts sedation. Severe pain management issues may arise from the reversal of opioid effects, but they are not a direct complication of naloxone itself. Increased appetite does not have a direct correlation with naloxone use and, therefore, is not relevant in this context.