Under what condition is paracetamol contraindicated?

Paracetamol is contraindicated in liver failure because the drug is metabolized primarily in the liver. In cases of liver failure, the liver's ability to process paracetamol is significantly impaired, which can lead to an accumulation of toxic metabolites. This increases the risk of severe liver damage and potential overdose, making the use of paracetamol unsafe in these patients. Monitoring liver function and avoiding nephrotoxic drugs, including paracetamol, is crucial in individuals with compromised liver health, as their bodies cannot safely handle the medication, thereby heightening the risk of adverse effects.

Hypertension, pregnancy, and bronchial asthma do not present the same level of risk concerning paracetamol. While there are considerations for dosing and use during pregnancy, it is not outright contraindicated. Similarly, in patients with hypertension or asthma, paracetamol can typically be used but should still be monitored and managed appropriately.